International Shock Congress
6th Congress of the International Federation of Shock Societies
31st Annual Conference on Shock
7th International Conference on
Complexity in Acute Illness
28- July 2, 2008 - Cologne,
On behalf of the European
Shock Society (ESS) it was a great pleasure and honor to welcome more
than 700 participants to the 6th Congress of the International
Federation of Shock Societies (IFSS) in Cologne from June 28 th –July 2.
2008. Thanks to the decision of the officers of the US-shock society and
the Society for Complexity in Acute Illness this Congress was also the
host for the 31st Annual Conference on Shock of
the US Shock Society and the 7th International
Conference on Complexity in Acute Illness (ICCAI) both integrated in the
five days meeting of the world‘s leading clinicians and researchers in
the field of trauma, sepsis and intensive care medicine.
The keynote of this conference was:
Translational Research – From the Bedside to the
Bench and Back.
This keynote intended to narrow the gap between basic
and clinical research for the overall benefit of our patients. In
retrospect I can summarize, that we have achieved this goal by intensive
interdisciplinary cross talks between clinicians and bench scientists
from in the different fields of shock represented by the membership of
The program was structured into three main parts with
21 symposia on trauma, sepsis and intensive care medicine running in
parallel. In addition, we had two plenary sessions, award sessions,
lunch symposia and most important two large structured poster sessions
in all fields of shock. 381 posters were accepted for presentation all
of them published in our journal shock.
This proceedings book compiles only a small number of
presentations given at the meeting, however, gives an overview of the
wide margin of this emerging field of Trauma, Sepsis and Intensive Care.
Thanks to all of you who contributed to this up to date volume.
A special recognition was given to our former leaders
in the field of shock, who passed away much too early. We named the
three main lecture halls t o Günther Schlag from Austria- he was the
host of our first international congress in 1991 in vienna together with
Heinz Redl, to Mohamed Sayeed, the president of the US shock society in
1998-1999 and Juretta Horton, who passed away last year and was
president in 1999-2000. Plaques at the entrances of the rooms gave infos
about their personal and professional life. The texts of the plaques are
published in the proceedings as well.
We as scientists and clinicians know about the great
lacks of knowledge to prevent fatal outcome of shock – the public does
not. The presidents of the participating Shock Societies therefore
decided to go public with a "Cologne Declaration on Shock" in
order to get an improved awareness by politicians, the public and our
funding organisations.Thanks to all Presidents for signing the
Declaration. The text of the Declaration is published also in this
Translation of research results to products in
diagnostics and therapeutics needs partnerships with the industry. In
order to facilitate these collaborations, we decided to include our
partners from the industry with lunch symposia and an industrial
exhibition.I herewith thank all of them for their support and
presentations of their newest acchievements.
Finally, I would like to thank the International and
National Program Committee, the organizers of the different symposia for
their help to set up this most interesting program as well as the
Medimond publishers, especially Dr. Eleonora Leardini for their
willingness and support in preparing this proceedings book.
Cologne- Witten/Herdecke September 2008
Edmund A.M. Neugebauer
– Basic Research
Fibrinogen and Trauma
Beneficial Effects of Ethyl Pyruvate in a Mouse Model
of Spinal Cord Injury
T. Genovese, E. Esposito, E. Mazzon, R. Di Paola, R. Meli, P.
Bramanti, M.P. Fink and S. Cuzzocrea
GITR-FC Fusion Protein Inhibits GITR Triggering and
Protects from the Inflammatory Response Following Spinal Cord Injury
T. Genovese, G. Nocentini, S. Cuzzocrea, R. Bianchini, E. Mazzon, S.
Ronchetti, E. Esposito, R. Di Paola, A. Cappelani, P. Bramanti and C.
TLR Ligands Differentially Regulate Pulmonary Sepsis
H. Ehrentraut, R. Meyer, M. Schwederski, M. Velten, A. Hoeft, P.
Knüfermann and G. Baumgarten
17-DMAG Inhibits Hemorrhage-induced Injury in Small
Intestine and Lung by Inactivating Caspase-3
J.G. Kiang, S.C. Kiang and P.D. Bowman
Green Tea Polyphenol Extract Ameliorates Pancreatic
Injury in Caerulein-induced Murine Acute Pancreatitis
T. Genovese, BI. Babu, E. Mazzon, R. Di Paola, C. Crisafulli, G.
Malleo, R. Caminiti, A. Cappelani AK. Siriwardena and S. Cuzzocrea
Interaction of the Complement and Coagulation System
During Hemorrhagic Shock After Severe Trauma
M. Huber-Lang, F. Gebhard and U.B. Brückner
– Clinical Research
Multiple Injury and Coagulation
O. Grottke and R. Rossaint
Intracranial Injury in the Setting of Multiple Trauma
Early Total Care vs. Damage Control Orthopedics
D. Rixen and E. Steinhausen
Hospital-based Trauma Registry and TRISS for
Improving Injury Surveillance and Developing the Resources
L. Fattori, G. Pesenti, C. Marradi, A. Intelisano and A. Nespoli
Sepsis/Inflammation – Basic
The Role of IL-18 in Apoptosis Induction of Bone
Marrow Graneulocyte During Systemic Inflammation in Mice
M. Aoyama, J. Kotani, M. Miyoshi, H. Sakaki, S. Shuno, M. Watanabe,
M. Usami and S. Marukawa
Ethyl Pyruvate Reduces the Development of Zymosan
Induced Generalized Inflammation in Mice
T. Genovese, R. Di Paola, E. Mazzon, C. Crisafulli, P. Bramanti, A.
Cappelani, R. Caminiti, E. Esposito, M.P. Fink and S. Cuzzocrea
Effects of Endothelial Selective Blockade of NF-kB On
Septic Multiple Organ Injury and Bacterial Clearance
X. Ye, J. Ding and S.F. Liu
Sexual Dimorphism in the Relationship of Il-18 to
Splenocyte Apoptosis and Mortality During Systemic Inflammation
M. Watanabe, M. Aoyama, S. Fudo, K. Shuno, M. Usami, S. Marukawa and
– Clinical Research
Inflammation: Gut Feeling?
T. Lubbers, J. De Haan, M. Luyer, J. Greve and W. Buurman
Use of Biomarkers to Guide Antibiotic Therapy
P. Schuetz, M. Christ-Crain and B. Müller
The Effects of ex-vivo Administration of
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Endotoxin
on Cytokine Release of Whole Blood Are Determined by Priming Sequence
J. Linssen, D.P. Frings, B. Montag, C. Kaltschmidt, S. Kluge, K.G.
Kreymann and A. Nierhaus
Multiplex PCR vs. Blood Culture: Towards a New Gold
Standard in Sepsis Diagnostics
S. Sachse, M. Lehmann, R. Schmitz, K. Reinhart and E. Straube
Prognostic Factors Between Young and Elderly Groups
in a Severe Head Injury – Significance of CPP Management in Geriatric
Head Injured Patients –
S. Yokobori, T. Masuno, T. Suzuki, H. Sato, A. Fuse, T. Araki, T.
Atsumi, M. Kitazono and H. Yokota
Tumor Necrosis Factor-a (TNF-a) Gene -238 Single
Nucleotide Polymorphism (SNP) Is Associated with Low TNF-a Production
from Peripheral Blood Mononuclear Cells (PBMCs) in Japanese
K. Shuno, M. Aoyama, S. Fudo, H. Sakaki, M. Miyoshi, M. Usami, S.
Marukawa and J. Kotani
Urine Production in the Septic Shock Patients with
Severe Viral Infections
Cardiac Autonomic Dysfunction in Cardiogenic and
Non-Cardiogenic-Triggered Multiple Organ Dysfunction Syndrome (MODS) and
the Use of b-Blockers
R. Hennen, I. Friedrich, D. Hoyer, J. Peinhardt, M. Rauchhaus, R.
A. Schlitt, U. Müller-Werdan, M. Buerke, K. Werdan and H. Schmidt
Endotoxin Inhibits the Pacemaker Current lf
RAGE Isoforms Expressed in Tissues and Cell Lines
J.V. Gefter, M.P. Fink and R.L. Delude
Cardiotropic Effects of Relaxin on Myocardial
Infarction and Adverse Post-ischemic Remodelling and Heart Failure
R. Mastroianni, S. Nistri, L. Formigli, E. Ragazzo, L. Cinci, D. Bani
and E. Masini
Lung Inflammation Following Cardiogenic Shock
X. Lin, K. Koga, Y. Zhang, K. Takahashi, H. Linge, C.N. Metz, K.
Ojamaa and E.J. Miller
Biological Allofibroblast-based Dressing Decreases
the Duration of Superficial Burn Healing
E.A. Zhirkova, S.V. Smirnov, L.L. Mironova, O.I. Koniushko, M.V.
Sychevsky, E.G. Kolokolchikova, V.B. Khvatov, K.S. Smirnov and V.S.