International Shock Congress

6th Congress of the International Federation of Shock Societies
31st Annual Conference on Shock
7th International Conference on Complexity in Acute Illness

 June 28- July 2, 2008 -  Cologne, Germany



On behalf of the European Shock Society (ESS) it was a great pleasure and honor to welcome more than 700 participants to the 6th Congress of the International Federation of Shock Societies (IFSS) in Cologne from June 28 th –July 2. 2008. Thanks to the decision of the officers of the US-shock society and the Society for Complexity in Acute Illness this Congress was also the host for the 31st Annual Conference on Shock of the US Shock Society and the 7th International Conference on Complexity in Acute Illness (ICCAI) both integrated in the five days meeting of the world‘s leading clinicians and researchers in the field of trauma, sepsis and intensive care medicine.

The keynote of this conference was:

Translational Research – From the Bedside to the Bench and Back.

This keynote intended to narrow the gap between basic and clinical research for the overall benefit of our patients. In retrospect I can summarize, that we have achieved this goal by intensive interdisciplinary cross talks between clinicians and bench scientists from in the different fields of shock represented by the membership of our societies.

The program was structured into three main parts with 21 symposia on trauma, sepsis and intensive care medicine running in parallel. In addition, we had two plenary sessions, award sessions, lunch symposia and most important two large structured poster sessions in all fields of shock. 381 posters were accepted for presentation all of them published in our journal shock.

This proceedings book compiles only a small number of presentations given at the meeting, however, gives an overview of the wide margin of this emerging field of Trauma, Sepsis and Intensive Care. Thanks to all of you who contributed to this up to date volume.

A special recognition was given to our former leaders in the field of shock, who passed away much too early. We named the three main lecture halls t o Günther Schlag from Austria- he was the host of our first international congress in 1991 in vienna together with Heinz Redl, to Mohamed Sayeed, the president of the US shock society in 1998-1999 and Juretta Horton, who passed away last year and was president in 1999-2000. Plaques at the entrances of the rooms gave infos about their personal and professional life. The texts of the plaques are published in the proceedings as well.

We as scientists and clinicians know about the great lacks of knowledge to prevent fatal outcome of shock – the public does not. The presidents of the participating Shock Societies therefore decided to go public with a "Cologne Declaration on Shock" in order to get an improved awareness by politicians, the public and our funding organisations.Thanks to all Presidents for signing the Declaration. The text of the Declaration is published also in this volume.

Translation of research results to products in diagnostics and therapeutics needs partnerships with the industry. In order to facilitate these collaborations, we decided to include our partners from the industry with lunch symposia and an industrial exhibition.I herewith thank all of them for their support and presentations of their newest acchievements.

Finally, I would like to thank the International and National Program Committee, the organizers of the different symposia for their help to set up this most interesting program as well as the Medimond publishers, especially Dr. Eleonora Leardini for their willingness and support in preparing this proceedings book.

Cologne- Witten/Herdecke September 2008

Edmund A.M. Neugebauer

Congress President





Trauma/Haemorrhage – Basic Research


Fibrinogen and Trauma

W.Z. Martini


Beneficial Effects of Ethyl Pyruvate in a Mouse Model of Spinal Cord Injury

T. Genovese, E. Esposito, E. Mazzon, R. Di Paola, R. Meli, P. Bramanti, M.P. Fink and S. Cuzzocrea

GITR-FC Fusion Protein Inhibits GITR Triggering and Protects from the Inflammatory Response Following Spinal Cord Injury

T. Genovese, G. Nocentini, S. Cuzzocrea, R. Bianchini, E. Mazzon, S. Ronchetti, E. Esposito, R. Di Paola, A. Cappelani, P. Bramanti and C. Riccardi


TLR Ligands Differentially Regulate Pulmonary Sepsis Mediators

H. Ehrentraut, R. Meyer, M. Schwederski, M. Velten, A. Hoeft, P. Knüfermann and G. Baumgarten


17-DMAG Inhibits Hemorrhage-induced Injury in Small Intestine and Lung by Inactivating Caspase-3

J.G. Kiang, S.C. Kiang and P.D. Bowman


Green Tea Polyphenol Extract Ameliorates Pancreatic Injury in Caerulein-induced Murine Acute Pancreatitis

T. Genovese, BI. Babu, E. Mazzon, R. Di Paola, C. Crisafulli, G. Malleo, R. Caminiti, A. Cappelani AK. Siriwardena and S. Cuzzocrea


Interaction of the Complement and Coagulation System During Hemorrhagic Shock After Severe Trauma

M. Huber-Lang, F. Gebhard and U.B. Brückner




Trauma/Haemorrhage – Clinical Research

Multiple Injury and Coagulation

O. Grottke and R. Rossaint


Intracranial Injury in the Setting of Multiple Trauma

D. Livingston


Early Total Care vs. Damage Control Orthopedics

D. Rixen and E. Steinhausen


Hospital-based Trauma Registry and TRISS for Improving Injury Surveillance and Developing the Resources

L. Fattori, G. Pesenti, C. Marradi, A. Intelisano and A. Nespoli


Sepsis/Inflammation – Basic Research

The Role of IL-18 in Apoptosis Induction of Bone Marrow Graneulocyte During Systemic Inflammation in Mice

M. Aoyama, J. Kotani, M. Miyoshi, H. Sakaki, S. Shuno, M. Watanabe, M. Usami and S. Marukawa


Ethyl Pyruvate Reduces the Development of Zymosan Induced Generalized Inflammation in Mice

T. Genovese, R. Di Paola, E. Mazzon, C. Crisafulli, P. Bramanti, A. Cappelani, R. Caminiti, E. Esposito, M.P. Fink and S. Cuzzocrea


Effects of Endothelial Selective Blockade of NF-kB On Septic Multiple Organ Injury and Bacterial Clearance

X. Ye, J. Ding and S.F. Liu


Sexual Dimorphism in the Relationship of Il-18 to Splenocyte Apoptosis and Mortality During Systemic Inflammation

M. Watanabe, M. Aoyama, S. Fudo, K. Shuno, M. Usami, S. Marukawa and J. Kotani



Sepsis/Inflammation – Clinical Research


Inflammation: Gut Feeling?

T. Lubbers, J. De Haan, M. Luyer, J. Greve and W. Buurman


Use of Biomarkers to Guide Antibiotic Therapy

P. Schuetz, M. Christ-Crain and B. Müller


The Effects of ex-vivo Administration of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Endotoxin on Cytokine Release of Whole Blood Are Determined by Priming Sequence

J. Linssen, D.P. Frings, B. Montag, C. Kaltschmidt, S. Kluge, K.G. Kreymann and A. Nierhaus


Multiplex PCR vs. Blood Culture: Towards a New Gold Standard in Sepsis Diagnostics

S. Sachse, M. Lehmann, R. Schmitz, K. Reinhart and E. Straube


Prognostic Factors Between Young and Elderly Groups in a Severe Head Injury – Significance of CPP Management in Geriatric Head Injured Patients –

S. Yokobori, T. Masuno, T. Suzuki, H. Sato, A. Fuse, T. Araki, T. Atsumi, M. Kitazono and H. Yokota


Tumor Necrosis Factor-a (TNF-a) Gene -238 Single Nucleotide Polymorphism (SNP) Is Associated with Low TNF-a Production from Peripheral Blood Mononuclear Cells (PBMCs) in Japanese

K. Shuno, M. Aoyama, S. Fudo, H. Sakaki, M. Miyoshi, M. Usami, S. Marukawa and J. Kotani


Urine Production in the Septic Shock Patients with Norepinephrine

Untung Widodo





Severe Viral Infections

M. Bray


Cardiac Autonomic Dysfunction in Cardiogenic and Non-Cardiogenic-Triggered Multiple Organ Dysfunction Syndrome (MODS) and the Use of b-Blockers

R. Hennen, I. Friedrich, D. Hoyer, J. Peinhardt, M. Rauchhaus, R. Prondzinsky,
A. Schlitt, U. Müller-Werdan, M. Buerke, K. Werdan and H. Schmidt


Endotoxin Inhibits the Pacemaker Current lf

K. Zorn-Pauly


RAGE Isoforms Expressed in Tissues and Cell Lines

J.V. Gefter, M.P. Fink and R.L. Delude


Cardiotropic Effects of Relaxin on Myocardial Infarction and Adverse Post-ischemic Remodelling and Heart Failure

R. Mastroianni, S. Nistri, L. Formigli, E. Ragazzo, L. Cinci, D. Bani and E. Masini


Lung Inflammation Following Cardiogenic Shock

X. Lin, K. Koga, Y. Zhang, K. Takahashi, H. Linge, C.N. Metz, K. Ojamaa and E.J. Miller


Biological Allofibroblast-based Dressing Decreases the Duration of Superficial Burn Healing

E.A. Zhirkova, S.V. Smirnov, L.L. Mironova, O.I. Koniushko, M.V. Sychevsky, E.G. Kolokolchikova, V.B. Khvatov, K.S. Smirnov and V.S. Bocharova



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